If they saw for human genes with significantly higher or lower expression levels.

If they saw for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with a reduced expression. Were while only ten % of the genes in the entire array of transcription factors, were 42 % of patients with an increased expression in humans. None of those with lower expression were transcription factors. This pattern, the authors note, directional selection. .

By altering transcription factors, the entire regulatory network change with very few mutations to. The effect and minimize the risk – ‘The big question,’he said, why the people are so different, what kind of changes in the environment or lifestyle such a rapid such a rapid shift in the expression of genes – in this case in the liver – in humans and no other primate? ‘.. Previous studies have shown that many of these genes rapidly rapidly in humans, its coding and accumulating changes in expression levels. ‘Together,’they add, ‘these findings raise the possibility that the function and regulation of transcription factors have been substantially modified in the human lineage. (more…)

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